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Light promoted aqueous phase amine synthesis via three-component coupling reactions
张丽娜 / 石峰
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By applying a simple TiO2–(NH4)2S2O8 system and promoted by UV light, the three-component reactions of cyclic ether, aniline and aldehyde can be progressed efficiently. 29 substituted amines with different structures were synthesized with up to 97% isolated yields. Isotope effect study revealed that the ratedetermining step might be the nucleophilic addition step but not radical generation.

Keywords: Amine; Imine; Heterogeneous catalysis; Light

★★★★☆ Lina Zhang,Deng YQ,Shi F. Light Promoted Aqueous Phase Amine Synthesis Via Three-component Coupling Reactions[J]. Tetrahedron Letters,2013,54:5217-5219.