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Eli Lilly’s demethylating process based on ionic liquid

Author:    Release time:2014-04-14 16:30:36      Reading times:

Eli Lilly have described a process for demethylating an aryl ether to quantitatively generate a phenol, on both a twenty-two litre and a 190 litre pilot plant scale. 4-Methoxyphenylbutanoic acid is demethylated in three hours
at 180 ℃ when melted with pyridinium hydrochloride, [pyH]Cl. 4-Hydroxyphenylbutanoic acid, which is the product, is an important pharmaceutical intermediate.

礼来公司(Eli Lilly)开发的基于<a href= target=_blank class=infotextkey>离子液体</a>的脱烷基化工艺.jpg


1. Natalia V. Plechkova and Kenneth R. Seddon. Chem. Soc. Rev., 2008, 37, 123–150.
2.  Schmid C R,Beck C A,Cronin J S,et al. Demethylation of 4-methoxyphenylbutyric acid using molten pyridinium hydrochloride on multikilogram scale[J]. Org. Proc. Res. Dev.,2004,8(4):670-673.


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