Your Current Location is：Home > Application
Eli Lilly’s demethylating process based on ionic liquid
Author: Release time:2014-04-14 16:30:36 Reading times:
Eli Lilly have described a process for demethylating an aryl ether to quantitatively generate a phenol, on both a twenty-two litre and a 190 litre pilot plant scale. 4-Methoxyphenylbutanoic acid is demethylated in three hours
at 180 ℃ when melted with pyridinium hydrochloride, [pyH]Cl. 4-Hydroxyphenylbutanoic acid, which is the product, is an important pharmaceutical intermediate.
1. Natalia V. Plechkova and Kenneth R. Seddon. Chem. Soc. Rev., 2008, 37, 123–150.
2. Schmid C R，Beck C A，Cronin J S，et al. Demethylation of 4-methoxyphenylbutyric acid using molten pyridinium hydrochloride on multikilogram scale[J]. Org. Proc. Res. Dev.，2004，8（4）：670-673.
-
Research Institute
-
Application Area
-
Ionic Liquids Used